SYNOZ

For the relief of pain

SYNOZ shall be used for the relief of pain and stiffness of the knee joint and other synovial joints in patients with degenerative and traumatic changes to the synovial joint.

The performance of the product is due to its biocompatibility and physico-chemical properties. The sodium hyaluronate is a biopolymer composed of repeating disaccharide units of N-acetylglucosamine and glucuronic acid and though it is biosynthesised by the bacterium Streptococcus equi it has been shown to be the same as the sodium hyaluronate which is found in the human body. The hyaluronan supplements the hyaluronan found naturally in the synovium but which has been depleted by the onset of osteoarthritis of the knee.

SYNOZ Sodium hyaluronate is manufactured by fermentation of Streptococcus equi and rigorously purified

INDICATIONS
A synovial viscosupplement for the relief of pain and stiffness of the knee joint and other synovial joints in patients with degenerative and traumatic changes to the synovial joint.

DIRECTIONS OF USE
The dosage regimen is injection into the affected synovial joint space once a week for up to five injections depending on the severity of the degenerative or traumatic change to the synovial joint.
The recommended dosage regimen for patients with mild to moderate osteoarthritis of the knee joint is up to five weekly injections of 2.0ml into the synovial space of the knee joint.

The injection procedure is as follows:
Clean the skin around the injection site with antiseptic and allow to dry before the injection is given.
If joint effusion is present it should be aspirated before injection of SYNOZ.
The contents of the syringe are sterile and should be injected using a sterile needle of an appropriate size (19 to 20 gauge is recommended).